terça-feira, 6 de setembro de 2011
Seminário "Cuidados Centrados no Desenvolvimento do Recém-Nascido"
quinta-feira, 30 de junho de 2011
The Risk of Necrotizing Enterocolitis After Indomethacin Tocolysis
Background: Postnatal indomethacin is reportedly associated with an increased incidence of necrotizing enterocolitis (NEC) in preterm infants. Because indomethacin readily crosses the placenta, we hypothesized that antenatal indomethacin (AI) would increase the risk for NEC in preterm infants.
Objective: The goal of this study was to explore the association between AI and NEC in preterm infants.
Methods: Medical records of preterm infants, 23 to 32 weeks' gestational age, without major congenital anomalies, were reviewed. Maternal and neonatal data were abstracted. Association of AI within 15 days before delivery (predictor variable) and classification of NEC according to modified Bell's stage 2a or higher in the first 15 days after delivery (early NEC [primary outcome variable]) was explored by using bivariate analyses, multivariate logistic regression, and propensity score analysis.
Results: Of 628 eligible infants, 63 received AI and 28 developed early NEC. AI exposure was significantly associated with multiple gestation, race, antenatal corticosteroids and magnesium sulfate, lower birth weight and gestational age, umbilical arterial catheter placement, respiratory distress syndrome, postnatal vasopressors and antibiotics, patent ductus arteriosus, sepsis, NEC, intraventricular hemorrhage, and mortality. On multivariate logistic regression controlling for covariates, AI was significantly associated with early NEC (adjusted odds ratio: 7.193 [95% confidence interval: 2.514–20.575]; number needed to harm: 5). The results remained significant when analyses were repeated using AI exposure within 5 days before delivery as a predictor variable; on analyses stratified according to gestational age; and on propensity score analysis.
Conclusions: AI was associated with NEC in preterm infants in the first 15 days of life in this study, as were multiple other clinical factors.
- Beena G. Sood, MD, MSa,b,
- Mirjana Lulic-Botica, RPha,b,
- Kelly A. Holzhausen, PharmDa,b,
- Sharon Pruder, RN, NNPa,b,
- Holly Kellogg, BSb,
- Vali Salari, PhDa,b,
- Ron Thomas, PhDb
quarta-feira, 11 de maio de 2011
Pain Reduction on Insertion of a Feeding Tube in Preterm Infants: A Randomized Controlled Trial
Objective: The aim of this study was to assess pain and discomfort during nasal insertion of a feeding tube, and to evaluate different measures for pain relief.
Methods: We included 24 preterm infants with postmenstrual age 28 to 32 weeks' who were in stable condition. Each infant acted as his or her own control over a 3-week period during which the tube was changed 6 times. On these occasions, 6 different treatment combinations were given in randomized order: pacifier or no pacifier, combined with no fluid, sterile water, or 30% sucrose. Pain and discomfort were assessed by at least 2 independent and experienced observers using a pain assessment tool, the Premature Infant Pain Profile; score range: 0 to 21. In general, scores of 4 to 6 are interpreted as normal or no discomfort; ≥12 usually signals significant pain and distress.
Results: The median Premature Infant Pain Profile score during the procedure was 9 and decreased gradually toward 4 after 5 minutes. The lowest pain score was achieved by combining a pacifier with oral sucrose. Sterile water without a pacifier gave the highest score.
Conclusions: Insertion of a feeding tube in preterm infants leads to a measurable degree of pain and discomfort, according to the Premature Infant Pain Profile assessment tool. Pain relief was best achieved by combining a pacifier with 30% sucrose.
- Laila Kristoffersen, RNa,
- Eirik Skogvoll, MD, PhDb,c,
- Mia Hafström, MD, PhDd
terça-feira, 3 de maio de 2011
Dificultades de lectura y escritura: percepción del profesorado ante el alumnado con antecedentes de prematuridad
Cidadania
segunda-feira, 31 de janeiro de 2011
Pós-Graduação em Enfermagem Cuidados Intensivos Neonatais - 4ª Edição (Faro)
quinta-feira, 16 de dezembro de 2010
Feliz Natal e Bom Ano Novo
quarta-feira, 29 de setembro de 2010
Pós graduação em enfermagem em cuidados intensivos neonatais no Algarve?
segunda-feira, 20 de setembro de 2010
I ENCONTRO DE NEONATOLOGIA
I ENCONTRO DE NEONATOLOGIA
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